pKa and Ka (Acid dissociation constant)
نویسندگان
چکیده
منابع مشابه
Quantum mechanics investigation of acid dissociation constant of carboxylic acids in aqueous solution
According to the Bronsted definition, any compound which has a hydrogen atom is an acid, since itmay be lost as a proton. A thermodynamical cycle is proposed to calculate absolute pKa values forBronsted acids in aqueous solution. The equilibrium of dissociation of a Bronsted acid depends onthe interaction of the acid and its conjugate base with solvent molecules. There fore the pKa valuedepends...
متن کاملApplication of Chemometrics in determination of the effects of ionic and non-ionic surfactants on ac-id dissociation constant (pKa) of Meloxicam using spectrophotometric method
The purpose of this study was to determine the acid dissociation constants (pKa) of meloxicam in the presence of various surfactants including sodium lauryl sulfate (SLS) as an anionic surfactant, cetyltrimethylammonium bromide (CTAB) as a cationic surfactant and Triton® TX-100 (TX-100) as a non-ionic surfactant in different pre-determined concentrations. The related pKa was determined spec...
متن کاملquantum mechanics investigation of acid dissociation constant of carboxylic acids in aqueous solution
according to the bronsted definition, any compound which has a hydrogen atom is an acid, since itmay be lost as a proton. a thermodynamical cycle is proposed to calculate absolute pka values forbronsted acids in aqueous solution. the equilibrium of dissociation of a bronsted acid depends onthe interaction of the acid and its conjugate base with solvent molecules. there fore the pka valuedepends...
متن کاملFirst Dissociation Constant of Succinic Acid from 0° to 50° G and Related Thermodynamic Quantities
The sensitivities of CH4 and CD4 differ by about 2 percent and are probably equal within the experimental uncertainty. The total ionization is apparently the same for CH4, CH3D, and CH?D2. The low value for CHD3 is not significant in view of the uncertainty in this spectrum. The difference in the total ionization of CH4 and CD4, however, is greater than the estimated error; and since the number...
متن کاملTotal weak acid concentration and effective dissociation constant of nonvolatile buffers in human plasma.
The strong ion approach provides a quantitative physicochemical method for describing the mechanism for an acid-base disturbance. The approach requires species-specific values for the total concentration of plasma nonvolatile buffers (A(tot)) and the effective dissociation constant for plasma nonvolatile buffers (K(a)), but these values have not been determined for human plasma. Accordingly, th...
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ژورنال
عنوان ژورنال: Southern African Journal of Anaesthesia and Analgesia
سال: 2020
ISSN: 2220-1173,2220-1181
DOI: 10.36303/sajaa.2020.26.6.s3.2552